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Department of Neurology | Department of Molecular and Human Genetics | Center for Alzheimer's and Neurodegenerative Diseases | |
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Publications
Papers 2021
Hill, EJ, Mangleburg, CG, Dunham-Alfradique, I, Ripperger, B, Stillwell, A, Rao, S, Saade, H, Fagbongbe, F, von Coelln, R, Jankovic, J, Dawe, R, Shulman, LM, Buchman, A, Shulman, JM. Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson's disease heterogeneity. Parkinsonism & Related Disorders. 2021; 84:105-111. [PDF] Guo, Q, Dammer, EB, Zhou, M, Kundinger, SR, Gearing, M, Lah, JJ, Levey, AI, Shulman, JM, Seyfried, NT. Targeted quantification of detergent-insoluble RNA-binding proteins in human brain reveals stage and disease-specific co-aggregation in Alzheimer's disease. Frontiers in Molecular Neuroscience. 2021; 14:623659. Bailey, M, Shulman, LM, Ryan, D, Ouyang, B, Shulman, JM, Buchman, AS, Bennett, DA, Barnes, LL, Hall, DA. Frequency of Parkinsonism and Parkinson Disease in African Americans in Community and Clinic Settings in Chicago. J Gerontol A 2021; 76:1340-1345. Abreha, MH, Ojelade S, Dammer, EB, McEachin, ZT, Duong, DM, Gearing, M, Bassell, GJ, Lah, JJ, Levey, AI, Shulman, JM*, Seyfried, NT*. TBK1 Interacts with Tau and Enhances Neurodegeneration in Tauopathy. Journal of Biological Chemistry. 2021; 296:100760 *Co-senior and Co-corresponding authors. [PDF ] Petyuk, VA, Yu, L, Olson, HM, Yu, F, Clair, G, Qian, W-J, Shulman, JM, Bennett, DA. Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss. Journal of Proteome Research. 2021; 20:2266-2282. [PDF ] 2020
Mangleburg, CG, Wu, T, Yalamanchili, H, Guo, C, Dammer, E, Hsieh, Y-C, De Jager, P Levey A, Seyfried, N, Liu, Z, Shulman, JM. Integrated analysis of the aging brain transcriptome and proteome in tauopathy. Molecular Neurodegeneration. 2020; 15:56. [PDF] Wan, Y-W, Al-Ouran, R, Mangleburg, CG, (. . .), Accelerating Medicines Partnership-Alzheimer's Disease Consortium, Liu, Z, Shulman, JM, Mangravite, L, Logsdon, B. Meta-analysis of the Alzheimer's disease brain transcriptome and functional dissection in mouse models. Cell Reports. 2020; 32:107908. [PDF] Robak, LA, Du, R, Yuan, B, Gu, S, Alfradique-Dunham, I, Kondapali, V, Hinojosa, E, Stillwell, A, young, E, Zhang, C, Song, X, Du, H, Gambin, T, Jhangiani, SN, Akdemir, ZC, Muzny, DM, Tejomurtula, A, Ross, OA, Shaw, C, Jankovic, J, Bi, W, Posey, J, Lupski, JR, Shulman, JM. Integrated Exome Sequencing and Array Comparative Genomic Hybridization in Familial Parkinson's Disease. Neurology Genetics. 2020; 6:e498 [PDF] Johnson, ECB, Dammer, EB, Duong, DM, Ping, L, Zhou, M, Yin, L, Higginbotham, LA, Guajardo, A, White, B, Troncoso, JC, Thambisetty, M, Montine, TJ, Lee, EB, Trojanowski, JQ, Beach, TG, Reiman, EM, Haroutunian, V, Wang, M, Schadt, E, Zhang, B, Dickson, DW, Ertekin-Taner, N, Golde, TE, Petyuk, VA, De Jager, PL, Bennett, DA, Wingo, TS, Rangaraju, S, Hajjar, I, Shulman, JM, Lah, JJ, Levey, AI, Seyfried, NT. Large-scale Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation. Nature Medicine. 2020; doi: 10.1038/s41591-020-0815-6 [PDF] Ye, H, Ojelade, S, Li-Kroeger, D, Zuo, Z, Duraine, L, He, Y, Li, Yarong, Tepass, U, Rodal, A, Wang, L, Bellen, HJ, Shulman, JM. The retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.eLife. 2020; 9:e51977.[Online: https://elifesciences.org/articles/51977] [PDF] Blauwendraat, C, Reed, X, Krohn, L, Heilbron, K, Bandres-Ciga, S, . . . Shulman LM, Jankovic, J, Shulman, JM, Morris, H, Cookson, MR, Nalls, MA, Gan-Or, Z, Singleton, AB. Genetic modifiers of risk and age of onset in GBA associated Parkinson's disease and Lewy body dementia. Brain. 2020; 143, 234-248. [PDF] 2019 Hsieh, Y-C, Guo, C, Yalamanchili, HK, Abreha, M, Al-Ouran, R, Li, Y, Dammer, E, Lah, JJ, Levey, AI, Bennett, DA, De Jager, PL, Seyfried, NT, Liu, Z, Shulman, JM. Tau-mediated disruption of the spliceosome triggers cryptic RNA splicing and neurodegeneration in Alzheimer's disease. Cell Reports.2019; 29, 301-316. [PDF] [Supplement]
von Coelln, R, Dawe, RJ, Leurgans, SE, Curran, TA, Truty, T, Yu, L, Barnes, LL, Shulman, JM, Shulman, LM, Bennett, DA, Hausdorff, JM, Buchman, AS. Quantitative mobility metrics derived from a wearable sensor predict incident parkinsonism in older adults. Parkinsonism and Related Disorders. 2019; pii: S1353-8020(19)30275-5. [PDF] Ysselstein, D, Shulman, JM, Krainc, D. Emerging Links Between Pediatric Lysosomal Storage Diseases and Adult Movement Disorders. Mov Disord. 2019; Epub doi: 10.1002/mds.27631 [PDF] Blauwedraat, C, Heilbron, K, Vallerga, CL, Bandres-Ciga S, von Coelln, R, Pihlstrom, L, Simon-Sanchez, J, Schulte, C, Sharma, M, Krohn, L, Siitonen, A, Iwaki, H, Leonard, H, Noyce, AJ, Tan, M, Gibbs, JR, Hernandez, DG, Sholz, SW, Jankovic, J, Shulman, LM, Lesage, S, Corvol, JC, Brice, A, van Hilten, JJ, Marinus, J; 23 and Me Research Team, Eerola-Rautio, J, Tienari, P, Majamaa, K, Toft, M, Grosset, DG, Gasser, T, Heutink, P, Shulman, JM, Wood, N, Hardy, J, Morris, HR, Hinds, DA, Gratten, J, Visscher, PM, Gan-Or, Z, Nalls, MA, Singleton, AB; International Parkinson's Disease Genomics Consortium. Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms. Movement Disorders. 2019; 34:866-875 [PDF] Buchman, AS, Yu, L, Wilson, RS, Leurgans, SE, Nag, S, Shulman, JM, Barnes, LL, Schneider, JA, Bennett, DA. Progressive parkinsonism in older adults is related to the burden of mixed-brain pathologies. Neurology. 2019; 92:e1821-e1830. [PDF] 2018 Rousseaux, M, Vazquez-Velez, G, Al-Ramahi, I, Jeong, H-H, Bajic, A, Revelli, J-P, Ye, H, Phan, E, Deger, J, Perez, A, Kim, J-Y, Lavery, L, Xu, Q, Li, M, Kang, H, Shulman JM, Westbrook, T, Ellegdge, S, Liu, Z, Botas, J, Zoghbi, H. A druggable genome screen identifies modifiers of α-synuclein levels via a tiered cross-species validation approach. J Neurosci. 2018; 3:9286-9301. [PDF] Rousseaux, M, Vazquez-Velez, G, Al-Ramahi, I, Jeong, H-H, Bajic, A, Revelli, J-P, Ye, H, Phan, E, Deger, J, Perez, A, Kim, J-Y, Lavery, L, Xu, Q, Li, M, Kang, H, Shulman JM, Westbrook, T, Ellegdge, S, Liu, Z, Botas, J, Zoghbi, H. A druggable genome screen identifies modifiers of α-synuclein levels via a tiered cross-species validation approach. Journal of Neuroscience. 2018; 3:9286-9301. [PDF] Guo, C, Hwang, J, Hsieh, Y-C, Klein, H-U, Bennet, D, De Jager, P, Liu, Z, Shulman JM. Tau Activates Transposable Elements in Alzheimer's disease. Cell Reports. 2018; 23,2874-2880. [PDF] Supplement-1 Jeong, H-H, Yalamanchili, HK, Guo, C, Shulman, JM, Liu, Z. An Ultra-Fast and Scalable Quantification Pipeline for Transposable Elements from Next Generation Sequencing Data. Pac Symp Biocomputing. 2018; 23:168-179. [PDF] Reply: Lysosomal storage disorder gene variants in multiple system atrophy. Brain. 2018; Epub. doi: 10.1093/brain/awy125. [PDF] 2017 Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J, International Parkinson's Disease Genomics Consortium (IPDGC), Heutink P, Shulman JM, IPDGC Consortium members. Excessive Burden of Lysosomal Storage Disorder Gene Variants in Parkinson's Disease. Brain. 2017; 12:3191-3203. [PDF] Wangler M, Hu, Y, Shulman, JM. Drosophila and Genome-wide Association Studies: a Review and Resource for the Functional Dissection of Human Complex Traits. Disease Models & Mechanisms. 2017; 10:77-88. [PDF] Chibnik, LC, White, CC, Mukherjee, S, Raj, T, Yu, L, Larson, EB, Montine, TJ, Keene, D, Sonnen, J, Schneider, JA, Crane, PK, Shulman, JM, Bennett, DA, De Jager PL. Uncovering the genetic architecture of neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies. Mol Psychiatry. Epub ahead of print. doi: 10.1038/mp.2017.20 [PDF] Blauwendraat C, Faghri, F, Geiger, JT, Nalls, MA . . . Robak, L, Shulman, JM, Rogaeva, E, Hardy, JA, Singleton, AB, Scholz, SW. NeuroChip, an updated version of the NeuroX genotyping platform, to rapidly screen for variants associated with neurological diseases. Neurobiol Aging. 2017; 57:247.e9e247.e13 [PDF] Rousseaux, MWC, Shulman, JM, Jankovic, J. Progress toward an integrated understanding of Parkinson's disease. F1000. F1000Research 2017; 6(F1000 Faculty Rev):1121 [PDF] Jansen, IE*, Ye, H*, Heetveld, S*, Lechler, M*, Michels, H, Seinstra, RI, Lubbe, SJ, Drouet, V, Lesage, S, Majounie, E, Gibbs, JR, Nalls, MA, Simon-Sanchez, J, Castillo, M, Rizzu, P, Blauwendraat, C, Chouhan, AK, Li, Y, Yogi, P, International Parkinson's Disease Genetics Consortium (IPGDC), Morris, H, Brice, A, Singleton, AB, David, DD, Nollen, EA, Jain, S, Shulman, JM*, Heutink, P*. Discovery and functional prioritization of Parkinson's Disease candidate genes from large-scale whole-exome sequencing. Genome Biology. 2017; 18:20. doi: 10.1186/s13059-017-1147-9 [PDF] 2016
Jakobsdottir, J, van der Lee, SJ, Bis, JC, Chouraki, V, Li-Kroeger, D, Yamamoto, S, Grove, ML, Naj, A, Vronskaya, M, Salazar, JL, DeStefano, AL, Brody, JA, Smith, AV, Amin, N, Sims, R, Ibrahim-Verbaas, CA, Choi, S-H, Satizabal, CL, Lopez, OL, Beiser, A, Ikram, MA, Garcia, ME, Hayward, C, Varga, TV, Ripatti, S, Franks, PW, Hallmans, G, Rolandsson, O, Jansson, J-H, Porteous, DJ, Salomaa, V, Eirkisdottir, G, Rice, KM, Bellen, HJ, Levy, D, Uitterlinden, AG, Emilsson, V, Rotter, JI, Aspelund, T, Cohorts for Heart and Aging Research in Genomic Epidemiology, Alzheimer's Disease Genetic Consortium, Genetic and Environmental Risk in Alzheimer's Disease, O'Donnell, CJ, Fitzpatrick, AL, Launer, LJ, Hofman, A, Wang, L-S, Williams, J, Schellenberg, GD, Boerwinkle, E, Psaty, BM, Seshadri, S, Shulman, JM*, Gudnason, V*, van Duijn, CM*. Rare loss-of-function variant in TM2D3 is associated with risk and onset of late-onset Alzheimer's disease. In revision. PLoS Genetics. 2016; 12(10):e1006327. doi: 10.1371/journal.pgen.1006327. [PDF] Hales, CW, Dammer, EB, Deng, Q, Duong, DM, Gearing, M, Troncoso, JC, Thambisetty, M, Lah, JJ, Shulman, JM, Levey, AI, Seyfried, NT. Early changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease. Proteomics. Epub ahead of print. doi: 10.1002/pmic.201600057. [PDF] Giri, A, Mok, KY, Jansen, I, Sharma, M, Tesson, C, Mangone, G, Lesage, S, Bras, JM, Shulman, JM, Sheering, U-M, International Parkinson's Disease Genetics Consortium (IPGDC), Diez-Fairen, M, Pastor, P, Marti, MJ, Ezquerra, M, Tolosa, E, Correia-Guedes, L, Ferreira, J, Amin, N, van Duijn, CM, van Rooij, J, Uitterlinden, AG, Kraaij, R, Nalls, M, Simon-Sanchez, J. Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population. Neurobiology of Aging. Epub ahead of print. http://dx.doi.org/10.1016/j.neurobiolaging.2016.10.004 [PDF] Chouhan, AK, Guo, C, Hsieh, Y-C, Senturk, M, Zuo, Zhongyuan, Li, Y, Chatterjee, S, Botas, J, Jackson, GR, Bellen, HJ, and Shulman, JM. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathologica Communications. 2016 4(1):62. doi: 10.1186/s40478-016-0333-4 [PDF] Valenca, GT, Srivastava, GP, Oliveira-Filho, J, White, CC, Yu, L, Schneider, JA, Buchman, AS, Shulman, JM, Bennett, DA, De Jager, PD. The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults. PLoS One. 2016; 11(7):e0157452. doi: 10.1371/journal.pone.0157452 [PDF] Ali, YO, Allen, HM, Yu, L, Li-Kroeger, D, Bakhshizadehmahmoudi, D, Hatcher, A, McCabe, C, Xu, J, Bjorklund, N, Taglialatela, G, Bennett, DA, De Jager, PL, Shulman, JM, Bellen, H, Lu, H-C. NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. PLoS Biology. 2016; 14(6): e1002472. doi:10.1371/journal.pbio.1002472 [PDF] 2015 Farlow, JL, Robak, LA, Hetrick, K, Bowling, K, Boerwinkle, E, Akdemir, ZC, Gambin, T, Gibbs, RA, Gu, S, Jain, P, Jankovic, J, Jhangiani, SN, Kaw, K, Lin, H, Ling, H, Liu, Y, Lupski, JR, Muzny, D, Porter, P, Pugh, E, White, J, Doheny, K, Myers, RM, Shulman, JM*, Foroud, T*. Whole exome sequencing identifies candidate genes for Parkinson’s disease. JAMA Neurology. Epub ahead of print, doi: 10.1001/jamaneurol.2015.3266 [PDF] Editorial by Toft and Ross Shulman, JM. Drosophila and experimental neurology in the post-genomic era. Experimental Neurology. 2015; Epub ahead of print, doi: 10.1016/j.expneurol.2015.03.016 [PDF] Debette, S, Ibrahim-Verbaas, CA, Bressler, J, Schuur, M, Smith, A, Bis, JC, Davies, G, Wolf, C, Gudnason, V, Chibnik, LB, Yang, Q, deStefano, A, de Quervain, DJF, Srikanth, V, Lahti, J, Grabe, HJ, Smith, JA, Priebe, L, Yu, L, Karbalai, N, Hayward, C, Wilson, JF, Becker, J, Stegle, O, Mather, KA, Chouraki, V, Sun, Q, Rose, LM, Resnick, S, Oldmeadow, C, Kirin, M, Wright, AF, Jonsdottir, MK, Au, R, Becker, A, Amin, N, Nalls, MA, Turner, ST, Kardia, SLR, Oostra, B, Windham, G, Coker, LH, Zhao, W, Knopman, DS, Heiss, G, Griswold, ME, Gottesman, RF, Vitart, V, Hastie, ND, Zgaga, L, Rudan, I, Polasek, O, Holliday, EG, Schofield, P, Hoan Choi, S, Tanaka, T, An, Y, Perry, RT, Kennedy, RE, Sale, MM, Wang, J, Wadley, VG, Liewald, DC, Ridker, PM, Gow, AJ, Pattie, A, Starr, JM, Porteous, D, Liu, X, Thomson, R, Armstrong, NJ, Eiriksdottir, G, Assareh, AA, Kochan, NA, Widen, E, Palotie, A, Hsieh, Y-C, Eriksson, JG, Vogler, C, van Swieten, JC, Shulman, JM, Beiser, A, Rotter, J, Schmidt, CO, Hoffman, W, Nothen, MM, Ferrucci, L, Attia, J, Uitterlinden, AG, Amouyel, P, Dartigues, J-F, Amieva, H, Raikkonen, K, Garcia, M, Wolf, PA, Hofman, A, Longstreth, WT, Psaty, BM, Boerwinkle, E, De Jager, PL, Sachdev, PS, Schmidt, R, Breteler, MMB, Teurner, A, Lopez, OL, Cichon, S, Chasman, DI, Grodstein, F, Muller-Myhsok, B, Tzourio, C, Papassotiropoulos, A, Bennett, DA, Ikram, MA, Deary, IJ, van Duijn, CM, Launer, L, Fitzpatrick, AL, Seshadri, S, and Mosley, TH for the CHARGE Consortium. Genome-wide studies of verbal declarative memory in non-demented older people: the cohorts for heart and aging research in genomic epidemiology consortium. Biol Psychiatry. 2015; 77:749-763. [PDF] Ibrahim-Verbaas, CA, Bressler, J, Debette, S, Schuur, M, Smith, AV, Bis, JC, Davies, G, Trompet, S, Smith, JA, Wolf, C, Chibnik, LB, liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffman, P, Karjalainen, J, Lahti, J, Llewellyn, DJ, Schmidt, CO, Mather, KA, Mather, KA, Chouraki, V, Sun, Q, Resnick, SM, Rose, LM, Oldmeadow, C, Stewar, M, Smith, BH, Gudnason, V, Yang, Q, Mirza, SS, Jukema, JW, De Jager, PL, Harris, TB, Liewald, DC, Amin, N, Coker, LH, Stegle, O, Lopez, OL, Schmidt, R, Teumer, A, Ford, I, Karbalai, N, Becker, JT, Jonsdottir, MK, Au, R, Fehrmann, RSN, Herms, S, Nalls, M, Zhao, W, Turner, ST, Yaffe, K, Lohman, K, van Swieten, JC, Kardia, SLR, Knopman, DS, Meeks, WM, Heiss, G, Holliday, EG, Schofield, PW, Tanaka, T, Stott, DJ, Wang, J, Ridker, P, Gow, AJ, Pattie, A, Starr, JM, Hocking, LJ, Armstrong, NJ, McLachlan, S, Shulman, JM, Pilling, LC, Eiriksdottir, G, Scott, RJ, Kochan, NA, Palotie, A, Hsieh, Y-C, Eriksson, JG, Penman, A, Gottesman, RF, Oostra, BA, Yu, L, DeStefano, AL, Beiser, A, Garcia, M, Rotter, JI, Nothen, MM, Hofman, A, Slagboom, PE, Westendorp, RGJ, Buckley, BM, Wolf, PA, Uitterlinden, AG, Psaty, BM, Grabe, HJ, Bandinelli, S, Chasman, DI, Grodstein, F, Raikkonen, Lambert, J-C, Porteous, Generation Scotland, Price, JF, Sachdev, PS, Ferrucci, Attia, JR, Rudan, I, Hayward, C, Wright, AF, Wilson, JF, Cichon, S, Franke, L, Schmidt, H, Ding, J, de Craen, AJM, Fornage, M, Bennett, DA, Deary, IJ, Ikram, MA, Launer, LJ, Fitzpatrick, AL, Seshadri, S, van Duijn, CM, and Mosley, TH. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry 2015; Epub ahead of print, doi: 10.1038/mp.2015.37 [PDF] 2014 Buchman, AS, Yu, L, Wilson, RS, Shulman, JM, Boyle, PA, Bennett, DA. Harm avoidance is associated with the rate of progressive parkinsonism in community-dwelling older persons: a prospective cohort study. BMC Geriatrics. 2014; 14:54. [PDF] Haelterman, NA, Yoon, WH, Sandoval, H, Jaiswal, M, Shulman, JM, Bellen, HJ. A mitocentric view of Parkinson’s Disease. Annual Review of Neuroscience. 2014; Epub ahead of print. [PDF] Buchman, AS, Yu, L, Wilson, RS, Shulman, JM, Boyle, PA, Bennett, DA. Harm avoidance is associated with the rate of progressive parkinsonism in community-dwelling older persons: a prospective cohort study. BMC Geriatrics. 2014; 14:54. [PDF] Shulman, JM, Yu, L, Buchman, AS, Evans, DA, Schneider, JA, Bennett, DA, De Jager, PL. Association of Parkinson Disease susceptibility loci with mild parkinsonian signs in older persons. JAMA Neurology. 2014; 71:429-35. [PDF] [Supplement] Shulman, JM, Imboywa, S, Giagtzoglou, N, Powers, MP, Hu, Yanhui, Devenport, D, Chipendo, P, Chibnik, LB, Diamond A, Perrimon, N, Brown, NH, De Jager PL, Feany, MB. Functional screening in Drosophila identifies Alzheimer’s disease susceptibility genes and implicates Tau-mediated mechanisms. Human Molecular Genetics. 2014; 23:870-877 [PDF] [Supplement-1] [Supplement-2] Sherva, R, Tripodis, Y, Bennett, D, Chibnik, LB, Crane, PK, De Jager, P, Farrer, LA, Saykin, AJ, Shulman, JM, Green, RC, ADNI. Genomewide Association Study of the Rate of Cognitive Decline in Alzheimer's Disease. Alzheimer's & Dementia. 2014; 10:45-52. [PDF] 2013
Chou, SH*, Shulman, JM*, Keenan, B, Secor, EA Buchman, AS, Schneider, JA, Bennett, DA, De Jager, PL. Genetic susceptibility for ischemic infarction and arteriosclerosis based on neuropathologic evaluations. Cerebrovascular Diseases. 2013; 36:181-8. [PDF] Shulman, JM, Chen, K, Keenan, BT, Chibnik, LB, Thiyyagura, P, Liu, X, Roontive, A, Yu, L, McCabe, C, Patsopoulos, NA, Corneveaux, JJ, Huentelman, MJ, ADNI, Evans, DA, Schneider, JA, Reimain, EM, De Jager, PL, Bennett, DA. Genetic susceptibility for Alzheimer's disease neuritic plaque pathology. JAMA Neurology. 2013; 70:1150-7. [PDF] Cruchaga, C, Kauwe, JSK, Harari, O, Jin, SC, Shulman, JM, De Jager, PL, Chibnik, LB, Bennett, DA, Arnold, SE, Van Deerlin, V, Lee, VM, Shaw, L, Trojanowski, J, Haines, JL, Mayeux, R, Pericak-Vance, MA, Farrer, LA, Schellenberg, GD, Peskind, ER, Galasko, D, Mayo, K, Bertelsen, S, Bailey, M, McKean, D, Fagan, AM, Holtzman, DM, Morris, JC, Alzheimer�s Disease Genetic Consortium, Alzheimer�s Disease Neuroimaging Initiative, GERAD Consortium, Goate, AM. A genome-wide association study for cerebrospinal fluid tau and phospho-tau levels identifies new candidate variants implicated in risk for Alzheimer's Disease. Neuron. 2013; 78:256-268. [PDF] 2012 Biffi, A, Shulman, JM, Jagiella, JM, Cortellini, L, Ayres, A, Schwab, K, Brown, DL, Silliman, SL, Selim, M, Worrall, BB, Meschia, JF, Slowik, A, De Jager, PL, Greenberg, SM, Schneider, JA, Bennett, DA, Rosand, J. Genetic Variation at CR1 Increases Risk and Severity of Cerebral Amyloid Angiopathy. Neurology. 2012; 78:334-341. [PDF] Buchman, AS, Shulman, JM, Nag, S, Leurgans, SE, Schneider, JA, and Bennett, DA. Nigral Pathology and Parkinsonian Signs in Elders without Parkinson's Disease. Annals of Neurology. 2012; 71:258-266. [PDF] De Jager, PL*, Shulman, JM*, Chibnik, LB*, Keenan, BT, Raj, T, Wilson, RS, Yu, L, Leurgans, SE, Tran, D, Aubin, C, Corneveaux, JJ, Huentelman, MJ, ADNI, Myers, AJ, Hardy, JA, Reiman, EM, Bennett, DA, and Evans, DA. A genome-wide scan for common variants affecting rate of age-related cognitive decline. Neurobiology of Aging. 2012; 33: 1017.e1-1017.e15. *Equal contribution. [PDF] Yu, L, Shulman, JM, Chibnik, L, Leurgans, S, Schneider, JA, De Jager, PL, Bennett, DA. The CETP I405V polymorphism is associated with increased risk of Alzheimer’s disease. Aging Cell. 2012; 11:228-233. [PDF] Raj, T, Shulman, JM, Keenan, BT, Chibnik, LB, Evans, DA, Bennett, DA, Stranger, BE, and De Jager, PL. Alzheimer’s disease susceptibility: evidence for a protein network under natural selection. American Journal of Human Genetics. 2012; 90:720-726. [PDF] Keenan, BT, Shulman, JM, Chibnik, LB, Raj, T, Tran, D, Sabuncu, MR, ADNI, Allen, A, Myers, AJ, Hardy, JA, Huentelman, MJ, Reiman, EM, Evans, DA, Bennett, DA, De Jager, PL. Functional fine-mapping of the CR1 locus identifies a causal variant. Human Molecular Genetics. 2012; 21:2377-2388. [PDF] Bis*, JC, DeCarli*, C, Smith*, AV, van der Lijn*, F, Crivello*, F, Fornage*, M, Debette*, S, Shulman, JM et al. Genome-wide association studies implicate loci on Chromosome 12 in hippocampal volume. Nature Genetics. 2012; 44:545-551. *Equal contribution. [PDF] Valant V, Keenan, BT, Anderson, CD, Shulman, JM, Devan, WJ, Ayres, AM, Schwab, K, Goldstein, JN, Viswanathan, A, Greenberg, SM, Bennett, DA, De Jager, PL, Rosand, J, Biffi, A, ADNI. TOMM40 in CAA-related ICH: Comparative Genetic Analysis with Alzheimer’s Disease. Translational Stroke Research. 2012; 3(S1):102-112. [PDF]
Hek, K, Demirkan, A, Lahti, J, ... Shulman, JM, ... Newman, AB, Tiemeier, H, Murabito, J. A Genome-Wide Association Study of Depressive Symptoms. Biological Psychiatry. In press. [PDF] Buchman, AS, Nag, S, Shulman, JM, Lim, ASP, VanderHorst, VGJM, Leurgans, SE, Schneider, JA, Bennett, DA. Locus Coeruleus Neuron Density and Parkinsonism in Older Adults without Parkinson’s Disease. Movement Disorders. 2012; 27:1625-1631. [PDF] Buchman, AS, Shulman, JM, Leurgans, SE, Schneider, JA, and Bennett, DA. Reply. Annals Neurol 2012; 72:298. Shulman, JM and Schneider, JA. Molecular mechanisms of cortical degeneration in Parkinson disease. Neurology. 2012; 79: 1750-1751. [PDF] 2011 Shulman, JM, Chipendo, PC, Chibnik, L.B., Keenan, B.T., Aubin, C, Tran, D, Kramer, P, Schneider, J.A., Bennett, DA, Feany, MB, De Jager, PL. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. American Journal of Human Genetics. 2011; 88:232-238. [PDF] Chibnik, LB, Shulman, JM, Leurgans, S, Shneider, JA, Wilson, RS, Tran, D, Aubin, C, Huentelman, MJ, Reiman, EM, Evans, DA, Bennett, DA, De Jager, PL. The Alzheimer’s susceptibility locus CR1 is associated with increased amyloid plaque burden and age-related cognitive decline. Annals of Neurology. 2011; 69:560-569. [PDF] Treusch, S, Hamamichi, S, Goodman, JL, Matlack, KES, Chung, CY, Baru, V, Shulman, JM, Parrado, A, Bevis, BJ, Valastyan, JS, Han, H, Lindhagen-Persson, M, Reiman, EM, Evans, DA, Bennett, DA, Olofsson, A, De Jager, PL, Tanzi, RE, Caldwell, KA, Caldwell, Shulman, JM, De Jager, PL, Feany, MB. Parkinson’s disease: Genetics and Pathogenesis. Annual Reviews of Pathology: Mechanisms of Disease 2011; 6:193-222. [PDF] 2010 Shulman, JM, Chibnik, LB, Aubin, C, Schneider, J, De Jager, P, and Bennett, D. Intermediate phenotypes identify divergent pathways to Alzheimer’s disease. PLoS ONE 2010; 5(6): e11244. [PDF] Xia, Z, Chibnik, LB, Glanz, BI, Liguori, M., Shulman, JM, Tran, D, Khoury, SJ, Chitnis, T, Holyoak, T, Weiner, HL, Guttmann, CRG, De Jager, PL. An Alzheimer's disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis. PLoS ONE 2010; 5(11): e14169. [PDF] Corneveaux, JJ, Myers, AJ, Allen, AN, Pruzin, JJ, Ramirez, M, Engel, A, Nalls, MA, Chen, K, Lee, W, Chewning, K, Villa, SE, Meechoovet, HB, Gerber, JD, Frost, D, Benson, HL, O'Reilly, S, Chibnik, LB, Shulman, JM, Singleton, A, Craig, DW, Van Keuren-Jensen, KR, Dunckley, T, Bennett, DA, De Jager, PL, Heward, C, Hardy, J, Reiman, EM, Huentelman, MJ. Association of CR1, CLU, and PICALM with Alzheimer's disease in a cohort of clinically and characterized and neuropathologically verified individuals. Human Molecular Genetics 2010; 19:3295-3301. [PDF] Shulman, JM. Incidence and Risk for Dementia in Parkinson Disease. Journal Watch: Neurology 2010; 12(4):28.
Shulman, JM and De Jager, P.L. Evidence for a common pathway linking neurodegenerative diseases. Nature Genetics 2009; 41:1261-1262. [PDF] 2008 Alcalay, RN, Shulman, JM, and Plotkin, SR. Ramsay Hunt syndrome in a patient with metastatic lung cancer to brain. Journal of Neurooncology 2008; 86:55-56. [PDF] 2007 Steinhilb, ML, Dias-Santagata, D, Mulkearns, EE, Shulman, JM, Biernat, J, Mandelkow, EM and Feany, MB. S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. Journal of Neuroscience Research 2007;85:1271-1278. [PDF] 2006 Khurana, V, Lu, Y, Steinhilb, M, Oldham, S, Shulman, JM, and Feany MB. TOR-mediated cell cycle activation causes neurodegeneration in a Drosophila tauopathy model. Current Biology 2006; 16:1-12. [PDF] 2005 Shulman, JM. Wing of Fly, Tail of Rodent, Scale of Fish, and Pinch of Yeast: Cooking Up the Ultimate Animal Model in Movement Disorders. Moving Along 2005;7(1):1. 2004 Shulman, JM. Surgical Lessons from Shakespeare. Current Surgery 2004; 61:96-97. 2003 Doerflinger, H, Benton, R, Shulman, JM, and St Johnston, D. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development 2003; 130:3965-3975. [PDF] Shulman, JM and Feany, MB. Genetic modifiers of tauopathy in Drosophila. Genetics 2003; 165:1233-1242. [PDF]
Shulman, JM, Shulman, LM, Weiner, WJ, and Feany, MB. From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease. Current Opinion in Neurology 2003; 16:443-449. [PDF] 2002 Tree, DRP, Shulman, JM, Gubb, D, and Axelrod, JD. Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 2002;109:371-381. [PDF] 2001 Huynh, J-R, Shulman, JM, Benton, R, and St Johnston, D. PAR-1 is required for the maintenance of oocyte fate in Drosophila. Development 2001; 128:1201-1209. [PDF] Wittman, CW, Wszolek, MF, Shulman, JM, Salvaterra, PM, Lewis, J, Hutton, M., Feany, MB. Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles. Science 2001; 293:711-714. [PDF] 2000 
Shulman, JM, Benton, R., and St Johnston, D. A Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell 2000; 101:377-388. [PDF] 1999 Shulman, JM and St Johnston, D. Pattern formation in single cells. Trends in Cell Biology 1999; 9:M60-M64. [PDF] 1998 Axelrod, JD, Miller, JR, Shulman, JM, Moon, RT, and Perrimon, N. Differential recruitment of Dishevelled provides signaling specificity in the Planar Cell Polarity and Wingless signaling pathways. Genes and Development 1998; 12:2610-2622. [PDF] Shulman, JM, Perrimon, N., and Axelrod, JD. Frizzled Signaling and the Developmental Control of Cell Polarity. Trends in Genetics 1998; 14:452-458. |
Dunham-Alfradique, I, Al-Ouran, R, von Coelln, R, Blauwendraat, C, Hill, EJ, Luo, L, Stillwell, A, Young, E, Tan, M, Liao, C, Hernandez, D, Pihlstrom, L, Grosset, D, Shulman, LM, Liu, Z, Rouleau, G, International Parkinson's Disease Genomics Consortium, Nalls, M, Singleton, A, Morris, H, Jankovic, J, Shulman, JM. Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes. Neurology Genetics. 2021; 7(2):e557. [
Yao, T, Nagorski, J, Sweeney, E, Shulman, JM, Allen, G. Quantifying Cognitive Resilience in Alzheimer's Disease: The Alzheimer's Disease Cognitive Resilience Score. PLoS One. 2020; 15:e0241707. [
Ojelade, S, Lee, T, Giagtzoglou, N, Yu, L, Ugur, B, Duraine, L, Zuo, Z, Petyuk, V, De Jager, PL, Bennett, DA, Arenkiel, BR, Bellen, H, Shulman JM. Cindr, the Drosophila homolog of the Alzheimer's disease risk gene, is required for synaptic transmission and proteostasis. Cell Reports. 2019; 28, 1799-1813. [
Muller, SH, Girard, SL, Hopfner, F, Merner, ND, Bourassa, CV, Lorenz, D, Clark, LN, Tittmann, L, Soto-Ortolaza, AI, Klebe, S, Hallett, M, Schneider, SA, Hodgkinson, CA, Lieb, W, Wszolek, ZK, Pendziwiat, M, Lorenzo-Betancor, O, Poewe, W, Ortega-Cubero, S, Seppi, K, Rajput, A, Hussl, A, Rajput, AH, Berg, D, Dion, PA, Wurster, I, Shulman, JM, Srulijes, K, Haubenberger, D, Pastor, P, Vilariño-Güell, C, Postuma, RB, Bernard, G, Ladwig, KH, Dupré, N, Jankovic, J, Strauch, K, Panisset, M, Winkelmann, J, Testa, CM, Reischl, E, Zeuner, KE, Ross, OA, Arzberger, T, Chouinard, S, Deuschl, G, Louis, ED, Kuhlenbäumer, G, Rouleau, GA. Genome-wide Association Study in Essential Tremor identifies three new loci. Brain. Epub ahead of print. doi: 10.1093/brain/aww242 [
Lim, ASP, Chang, AM, Shulman, JM, Raj, T, Chibnik, LB, Myers, AJ, Buchman, AS, Bennett, DA, Cain, SW, Czeisler, CA, Duffy, JF, Saper, CB, De Jager, PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Annals of Neurology. 2012; 72:324-334. PMCID: PMC3464954. 
GA, Lindquist, S. A yeast model establishes a functional connection between Aβ Toxicity and endocytic trafficking and Alzheimer’s Disease risk factors. Science. 2011; 334:1241-1245. 
2009
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